Our expertise lies in bioanalogic hydrogel technologies and porcine xenografts. To date, MEDICEM’s scientific team has helped to develop over a dozen products based on our proprietary bioanalogic hydrogel technologies and porcine xenografts. The products hold certifications in important medical markets such as the USA, Japan and the EU.
Our expertise derives from the knowledge on bioanalogic hydrogels, a concept applied already by Otto Wichterle. A brief history of bioanalogic hydrogels and their applications in the medical and related fields is summarized below.
1950 ... Biomaterial laboratory of professor Otto Wichterle
1956 ... First versions of pHEMA bioanalogic hydrogels
1960 ... Seminal paper on hydrogels by Wichterle and Lím
Wichterle and Lím, 1960. ‘Hydrophilic Gels for Biological Use’, Nature (185), 117–118.
1965 ... First contact lenses from pHEMA hydrogel manufactured by spin-casting and clinically tested
1970 ... pHEMA soft hydrogel contact lenses (Bausch & Lomb, USA)
1987 ... DILAPAN hydrogel cervical dilator (Gynotech, USA)
1988 ... TRIPLE CREAM regeneration and moisturizing cream (Estee Lauder, USA)
1989 ... EYEZONE repair gel, (Estee Lauder, USA)
1990 ... MEMORYLENS IOL (CIBA Vision, Switzerland)
1992 ... HYCREAM protective therapeutic cream (Kingston Technologies, USA)
DILAPAN-S improved hydrogel cervical dilator (Gel-Med International, Czech Republic)
WIGEL bioanalogic hydrogel for intraocular applications (BioVision, Czech Republic)
1995 ... E-Z-ON coatings for surgical gloves (Ansell, Australia)
2000 ... Prosthetic disc nucleus implant (Raymedica/Medtronic, USA)
2004 ... NUDISC nucleus pulposus prosthesis (Replication Medical, USA)
2005 ... HYDRILLIEN hydrogel emulsifier (LIPO Chemicals, USA)
2006 ... MERCURY transcorneal glaucoma shunt (Becton Dickinson, USA)
2007 ... AQUAMER coating for carotic filter (MedNova/Abbott Vascular Systems, Ireland/USA)
2012 ... WIOL-CF (Medicem, Czech Republic)
We currently focus on hydrogel applications for ophthalmic surgery. Our research aims at developing bioanalogic hydrogels that mimic the properties of various tissues. WIOL-CF, one of our products, is made from proprietary WIGEL hydrogel, which resembles a natural crystalline lens. In addition to developing new materials, we investigate visual and physiological optics (e.g., accommodation, polyfocality, contrast sensitivity, natural crystalline lens properties, etc.), biomaterial biocompatibility (i.e., cytotoxicity, cell growth and calcification) and transport processes within the eye. We take particular interest in intraocular lens (IOL) design, where we follow the bioanalogic approach.
ANALOGIES BETWEEN TISSUES AND HYDROGELS:
|cellular structure||...||3D network structure|
|high water content||...||high water content|
|free water presence||...||tree water presence|
|diffusive permeability||...||diffusive permeability|
|hydraulic permeability||...||hydraulic permeability|
|osmotic pressure||...||osmotic pressure|